Objective: Cardiovascular function assessment is most often mandatory required in preclinical studies in all industrialized countries. The invasiveness and impact of the monitoring devices used on animals have to be lowered as much as possible for scientific as well as ethical reasons. Continue reading
Respiratory monitoring is often required in experimental physiological and pharmacological studies in rodents. Currently, the mostly used techniques are direct measurement of airflow on intubated animals and whole body plethysmography.
Abstract : Cardiovascular monitoring is of great importance in pharmacology but there is a lack of convenient non-invasive alternatives. Hence, we aim to evaluate the relevance of inductive plethysmography (IP) in preclinical cardiac studies. An IP system was specifically designed for rat. Its evaluation carried out using a mechanical test bench has shown appropriate instrumental performances for cardiac monitoring in rats. Measurements were also performed during a volume overload hemodynamic challenge in vivo in rats. The cardiac output variation has similar kinetic and amplitude when compared to results of previous studies. This suggests that our system is suitable for cardiac output monitoring in rat.
Checkout the manuscript : https://ieeexplore.ieee.org/document/7591834/